cell degranulation การใช้

• At low concentrations, MCD peptide can stimulate mast cell degranulation.
• Absorption of this substance would exert an effect of perifollicular mast cell degranulation with releas of histamine.
• For example, IgE is responsible for an allergic response consisting of mast cell degranulation and histamine release.
• CGRP binding to its receptor will also promote mast cell degranulation and infiltration by neutrophils and other immune cells.
• Neurotensin is involved in many processes including mast cell degranulation and regulation of central nervous system dopaminergic and cholinergic circuits.
• They block a calcium channel essential for mast cell degranulation, stabilizing the cell, thus preventing the release of histamine.
• This CGRP then binds to and activates CGRP receptors located around meningeal vessels, causing vasodilation, mast cell degranulation, and plasma extravasation.
• The syndrome is diagnosed based upon four sets of criteria involving treatment response, symptoms, a differential diagnosis, and biomarkers of mast cell degranulation.
• The work showed that chemokines not only contribute to leukocyte recruitment, but can cooperate with other mast cell activation signals to trigger mast cell degranulation.
• The toxins are produced by peptides that have multiple actions, such as pain oedema formation, hemolysis, chemotaxis of PMLs and most cell degranulation.
• At least one clinical study suggested nifedipine, one of the dihydropyridines, may reduce mast cell degranulation in patients who exhibit " urticaria pigmentosa ".
• At least one clinical study suggested that nifedipine, a calcium channel blocker used to treat high blood pressure, may reduce mast cell degranulation in patients with urticaria pigmentosa.
• Cromoglicate-based drugs ( sodium cromoglicate, nedocromil ) block a calcium channel essential for mast cell degranulation, stabilizing the cell and preventing release of histamine and related mediators.
• Injectable codeine is available for subcutaneous or intramuscular injection only; intravenous injection is contraindicated as this can result in non-immune mast-cell degranulation and resulting anaphylactoid reaction.
• The P2X 7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death, regulation of receptor trafficking, mast cell degranulation, and inflammation.
• C3a is an effector of the complement system with a range of functions including T cell activation and survival, angiogenesis stimulation, chemotaxis, mast cell degranulation, and macrophage activation.
• Mast cell activation syndrome ( MCAS ) is an idiopathic immune disorder that involves recurrent and excessive mast cell degranulation and which produces symptoms that are similar to other mast cell activation disorders.
• Possible class effects of antibodies include : Opsonisation, agglutination, haemolysis, complement activation, mast cell degranulation, and neutralisation ( though this class effect may be mediated by the Fab region rather than the Fc region ).
• Meanwhile, in the intervening period, scientists at the former GlaxoWellcome Inc . had conducted further research and developed a proprietary buffer excipient formulation intended to mitigate the mast cell degranulation seen upon rapid intravenous administration of high concentration doses of agents such as GW280430A that are intrinsically cationic.
• In 1995, Kovanen et al . examined specimens of coronary arteries from 20 patients who had died of acute myocardial infarction and found that the degree of mast cell degranulation was much higher ( 200 to 1 ratio ) at the sites of plaque erosion or rupture than in adjacent areas or in the more distant unaffected areas [ 8 ].